A Ukrainian drone attack on Moscow damaged a building in a central business district, authorities said on Wednesday, in the sixth straight night of aerial attacks on Russia's capital region, AFP reported.

The Moscow region, hundreds of kilometers from the front line, has been repeatedly targeted in recent weeks, although there have been no reports of major damage.

Air defenses downed one Ukrainian drone in the Mozhaisky district and one in the Khimki district of the Moscow region, Russia's defense ministry said in a statement.

A third drone crashed into a building in the Moscow City business district around five kilometers (three miles) from the Kremlin after being "suppressed" by air defenses, it said.

Air traffic at Moscow's Vnukovo, Sheremetyevo, and Domodedovo airports was briefly halted, the TASS state news agency reported, citing the aviation services.

AFP images showed emergency services vehicles lined up along a street below a cluster of brightly-lit skyscrapers.

One window on a multi-story building had been blown out and black scorch marks surrounded its frame.

Emergency services were inspecting the area in the business district, Moscow mayor Sergei Sobyanin said on Telegram.

"Several windows were smashed in two adjacent five-story buildings," he said.

Sobyanin and the defense ministry said there were no reports of casualties.

In Khimki district, the wreckage of a downed drone had partially collapsed the roof of a private house and damaged a non-residential building, the RIA Novosti news agency reported.

There were no casualties, it reported.